Sustanon 250 History
Sustanon 250 first appeared on international drug markets during the early 1970’s. It was developed by the international pharmaceutical giant Organon (now Merck/MSD), also responsible for such steroids as Durabolin, Deca-Durabolin, and Andriol. Sustanon 250 was designed to offer a therapeutic advantage over existing single esters of testosterone, which need to be injected more frequently (cited advantages in hormone stability are probably not valid). In spite of this advantage, however, Sustanon 250 has never been approved for sale in the United States, although around the world it is one of the most popular brands of testosterone available. The lack of U.S. availability is probably due to the high costs associated with the FDA approval process and the availability of other somewhat comparable agents.
Over the past 25 years, Sustanon 250 has probably been the most sought-after injectable testosterone among athletes. It must be emphasized, however, that this is not due to an unusual potency of this testosterone combination (esters really only affect the release of testosterone). This is simply due to the fact that a stack of four different testosterone compounds is a very good selling point; it is perceived to have more value. In most instances you will actually get a lot more for your money with testosterone enanthate or cypionate. The advantages to be found in Sustanon 250 are for the medical user only. If you were tied to your doctor for regular injections, then Sustanon 250 would allow you to visit him or her less frequently. This equates to a clear improvement in patient comfort. But if you are a bodybuilder injecting the drug every week, blood levels will build to the same extremes with either type of testosterone, and the added expense is probably not warranted.
How is Sustanon 250 Supplied
Sustanon 250 is widely available in human and (select) veterinary drug markets. Packaging volume may vary by country and manufacturer; the majority of products are supplied as 1 mL glass ampules.
Structural Characteristics of Sustanon 250
Sustanon 250 contains a mixture of four testosterone compounds, which where modified with the addition of carboxylic acid esters (propionic, propionic phenyl ester, isocaproic, and decanoic acids) at the 17-beta hydroxyl group. Esterified forms of testosterone are less polar than free testosterone, and are absorbed more slowly from the area of injection. Once in the bloodstream, the ester is removed to yield free (active) testosterone. Esterified forms of testosterone are designed to prolong the window of therapeutic effect following administration, allowing for a less frequent injection schedule compared to injections of free (unesterified) steroid. Sustanon 250 is designed to provide a rapid peak in testosterone levels (24-48 hours after injection), and maintain physiological concentrations for approximately 21 days. Each 250 mg ampule provides 176mg of testosterone.
Sustanon 250 Side Effects (Estrogenic)
Testosterone is readily aromatized in the body to estradiol (estrogen). The aromatase (estrogen synthetase) enzyme is responsible for this metabolism of testosterone. Elevated estrogen levels can cause side effects such as increased water retention, body fat gain, and gynecomastia. Testosterone is considered a moderately estrogenic steroid. An anti-estrogen such as clomiphene citrate or tamoxifen citrate may be necessary to prevent estrogenic side effects. One may alternately use an aromatase inhibitor like Arimidex (anastrozole), which more efficiently controls estrogen by preventing its synthesis. Aromatase inhibitors can be quite expensive in comparison to anti-estrogens, however, and may also have negative effects on blood lipids.
Estrogenic side effects will occur in a dose-dependant manner, with higher doses (above normal therapeutic levels) of Sustanon 250 more likely to require the concurrent use of an anti-estrogen or aromatase inhibitor. Since water retention and loss of muscle definition are common with higher doses of testosterone, this drug is usually considered a poor choice for dieting or cutting phases of training. Its moderate estrogenicity makes it more ideal for bulking phases, where the added water retention will support raw strength and muscle size, and help foster a stronger anabolic environment.
Sustanon 250 Side Effects (Androgenic)
Testosterone is the primary male androgen, responsible for maintaining secondary male sexual characteristics. Elevated levels of testosterone are likely to produce androgenic side effects including oily skin, acne, and body/facial hair growth. Men with a genetic predisposition for hair loss (androgenetic alopecia) may notice accelerated male pattern balding. Those concerned about hair loss may find a more comfortable option in nandrolone decanoate, which is a comparably less androgenic steroid. Women are warned of the potential virilizing effects of anabolic/androgenic steroids, especially with a strong androgen such as testosterone. These may include deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement.
In androgen-responsive target tissues such as the skin, scalp, and prostate, the high relative androgenicity of testosterone is dependant on its reduction to dihydrotestosterone (DHT). The 5-alpha reductase enzyme is responsible for this metabolism of testosterone. The concurrent use of a 5-alpha reductase inhibitor such as finasteride or dutasteride will interfere with site-specific potentiation of testosterone action, lowering the tendency of testosterone drugs to produce androgenic side effects. It is important to remember that anabolic and androgenic effects are both mediated via the cytosolic androgen receptor. Complete separation of testosterone’s anabolic and androgenic properties is not possible, even with total 5-alpha reductase inhibition.
Sustanon 250 Side Effects (Hepatotoxicity)
Testosterone does not have hepatotoxic effects; liver toxicity is unlikely. One study examined the potential for hepatotoxicity with high doses of testosterone by administering 400 mg of the hormone per day (2,800 mg per week) to a group of male subjects. The steroid was taken orally so that higher peak concentrations would be reached in hepatic tissues compared to intramuscular injections. The hormone was given daily for 20 days, and produced no significant changes in liver enzyme values including serum albumin, bilirubin, alanine-amino-transferase, and alkaline phosphatases.
Sustanon 250 Side Effects (Cardiovascular)
Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.
Testosterone tends to have a much less dramatic impact on cardiovascular risk factors than synthetic steroids. This is due in part to its openness to metabolism by the liver, which allows it to have less effect on the hepatic management of cholesterol. The aromatization of testosterone to estradiol also helps to mitigate the negative effects of androgens on serum lipids. In one study, 280 mg per week of testosterone ester (enanthate) had a slight but not statistically significant effect on HDL cholesterol after 12 weeks, but when taken with an aromatase inhibitor a strong (25%) decrease was seen. Studies using 300 mg of testosterone ester (enanthate) per week for 20 weeks without an aromatase inhibitor demonstrated only a 13% decrease in HDL cholesterol, while at 600 mg the reduction reached 21%. The negative impact of aromatase inhibition should be taken into consideration before such drug is added to testosterone therapy.
Due to the positive influence of estrogen on serum lipids, tamoxifen citrate or clomiphene citrate are preferred to aromatase inhibitors for those concerned with cardiovascular health, as they offer a partial estrogenic effect in the liver. This allows them to potentially improve lipid profiles and offset some of the negative effects of androgens. With doses of 600 mg or less of testosterone per week, the impact on lipid profile tends to be noticeable but not dramatic, making an anti-estrogen (for cardioprotective purposes) perhaps unnecessary. Doses of 600 mg or less per week have also failed to produce statistically significant changes in LDL/VLDL cholesterol, triglycerides, apolipoprotein B/C-III, C-reactive protein, and insulin sensitivity, all indicating a relatively weak impact on cardiovascular risk factors.590 When used in moderate doses, injectable testosterone esters are usually considered to be the safest of all anabolic/androgenic steroids.
To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.
Sustanon 250 Side Effects (Testosterone Suppression)
All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Testosterone is the primary male androgen, and offers strong negative feedback on endogenous testosterone production.Testosterone-based drugs will, likewise, have a strong effect on the hypothalamic regulation of natural steroid hormones. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.
Sustanon 250 Administration (General)
Testosterone propionate is often regarded as a painful injection. This is due to the very short carbon chain of the propionic acid ester, which can be irritating to tissues at the site of injection. Many sensitive individuals choose to stay away from this steroid completely, their bodies reacting with a pronounced soreness and low-grade fever that may last for a few days after each injection.
Sustanon 250 Administration (Men)
To treat androgen insufficiency, the prescribing guidelines for Sustanon 250 call for a dosage of 250 mg every 3 weeks. Although active in the body for a longer time, Sustanon 250 is usually injected every 7 to 10 days for muscle-building purposes. This schedule will allow for the higher doses most commonly applied by athletes, and more stable elevations in hormone level. The usual dosage among male athletes is in the range of 250-750 mg per injection, taken in cycles 6 to 12 weeks in length. This level is sufficient for most users to notice exceptional gains in muscle size and strength.
Sustanon 250 is usually incorporated into bulking phases of training, when added water retention will be of little consequence, the user more concerned with raw mass than definition. Some do incorporate this drug into cutting cycles as well, but typically in lower doses (125- 250 mg every 7-10 days) and/or when accompanied by an aromatase inhibitor to keep estrogen levels under control. Sustanon 250 is a very effective anabolic drug, and is often used alone with great benefit. Some, however, find a need to stack it with other anabolic/androgenic steroids for a stronger effect, in which case an additional 200-400 mg per week of boldenone undecylenate, methenolone enanthate, or nandrolone decanoate should provide substantial results with no significant hepatotoxicity. Testosterone is ultimately very versatile, and can be combined with many other anabolic/androgenic steroids to tailor the desired effect.
Some bodybuilders have been known to use excessively high dosages of this drug (1,000 mg per week or more), although this practice is generally not advised. At dosages above 750 mg per week, water retention will likely account for more of the additional weight gain than new muscle tissue. The practice of “megadosing” is inefficient (not to mention potentially dangerous), especially when we take into account the typical high cost of Sustanon 250. Such use is usually not justified outside of aggressive bodybuilding regimens.
Sustanon 250 Administration (Women)
Sustanon 250 is rarely used with women in clinical medicine. When applied, it is most often used to induce masculinization in female to male transsexuals. Sustanon 250 is not recommended for women for physique- or performance-enhancing purposes due to its strong androgenic nature, tendency to produce virilizing side effects, and slow-acting characteristics (making blood levels difficult to control).
Sustanon 250 Availability
Sustanon remains a popular testosterone product in many countries outside of the United States. The vast majority of products in western markets are made by or under license from Organon (now Merck/MSD), though many “clone” products are also manufactured in less regulated markets of Asia. In reviewing some of the products and changes in the global pharmaceutical market, we have made the following observations.
In November 2007, Organon was purchased by Schering-Plough. In the two years following this acquisition, the company was slowly transitioning the Organon products over to the Schering-Plough label. In November 2009, Schering-Plough merged with Merck & Co, Inc. Sustanon is expected to transition over to the new Merck/MSD label in all markets, though packaging bearing the new company has not yet been located for photographing purposes. It is unknown what (if any) changes to expect in the global distribution of Sustanon.
In Brazil, Durateston in now widely available under the Schering-Plough label. The product is still produced in its familiar clear glass ampule with red and yellow band on the tip. Given the recent merger with MSD, it is expected that Durateston will soon be subject to another packaging change.
Omnadren from Jelfa (Poland) recently had its packaging updated. The new boxes have a more colorful pink gradient to them, but otherwise the presentation remains similar to the old product (a set of five 1 mL ampules in a rectangular box with ampule tray).
Unigen markets the product Test-Comp 250 in Thailand. It contains the standard 250 mg/mL dosage in a 10 mL multi-dose vial. Each product should carry a unique product ID code that can be verified with the company for authenticity.
Sustabolic from Asia Pharma (Malaysia) is now approved for sale through pharmacies in Thailand. Each box should carry a scratch-off security sticker, which will display a code that can be validated on the company website.
Balkan Pharmaceuticals (Moldova) makes the product Sustamed. It is prepared in both 1 mL ampules and multi-dose vials.
Sostenon 250 redi-jects manufactured by Organon/MSD in Mexico are also still found, although much less commonly in recent years. Due to the sophisticated packaging, this steroid has never been successfully counterfeited.
Less common, but still seen on the U.S. black market, are the European versions of Sustanon from countries like Italy, Portugal, Belgium, and England. All of these products use ampules that are scored, carry colored (yellow and red) rings on the tip, and have white paper labels.
Sustanon 250 from Karachi Pakistan is also popular as of late. These ampules are clear glass with yellow silk-screen printing. This is one of the few versions of this steroid product sold by Organon/MSD globally that does not carry a paper label. Fakes are circulating in high volume at this time. Note that the current real product has its lot numbers printed on with electronic equipment, and are not silk-screened on the glass at the same time as the rest of the lettering.
Sustanon 250mg is produced by Swiss Remedies and available across Europe. Due to numerous fakes of this product, Swiss Remedies offers a convenient online product checker.
Magnus Pharmaceuticals makes the product Sustanon 250 primarily for the EU and UK markets. Due to fake products appearing on the market, Magnus offers an online checker that lets steroid users verify their product originality.
This is a well structured product that acts as a well timed time-released high anabolic/high androgenic testosterone. In fact, due to TESTOSTERONE PROPIONATE, this product becomes active after one day, but through the series of the other 3 testosterones, remains active for 3 weeks. This mixture had a reported better over all effect milligram for milligram than any other testosterone alone. Users experienced a rapid increase in strength and an even increase in solid mass during administration. SUSTANON aromatized less and caused less water retention when compared to other single testosterones and much less than OMNADREN. Liver toxicity was low (Except in ridiculous dosages) as the liver metabolizes testosterone very efficiently. Like all testosterones, SUSTANON provided improved muscle pumps, better post-training recuperation, and an elevation in aggressiveness toward training.
SUSTANON significantly suppressed the HPTA so natural testosterone production was significantly decreased as well. For this reason, HCG and CLOMID were considered mandatory after 4-6 weeks of continuous use and after the discontinuance of the drug.
Males normally utilized dosages of 250-1000mg weekly, but some used higher dosages. As a rule, excellent results were realized with a dosage of 250-500mg every 7- 10 days. Most novices and women noted that they felt that they should not use testosterone. Novices…because it was not necessary and it will limit later potential progress. Women should not use them (but a few reported doing so) due to virilizing effects.
Some woman polled just could not leave testosterones alone. PROSCAR (FINASTERIDE, A DHT BLOCKER) was considered mandatory for co-administration and TESTOSTERONE PROPIONATE 50mg 1 time weekly was noted to cause less virilizing side effects.
Anabolic Steroid Guide reference
Sustanon is a very popular steroid which is highly appreciated by its users since it offers several advantages when compared to other testosterone compounds. Sustanon is a mixture of four different testosterones which, based on the well-timed composition, have a synergetic effect. This special feature has two positive characteristics for the athlete. First, based on the special combination effect of the compounds, Sustanon, milligram for milligram, has a better effect than Testosterone enanthate, cypionate, and propionate alone. Second, the effect of the four testosterones is time released so that Sustanon goes rapidly into the system and remains effective in the body for several weeks. Due to the propionate also included in the steroid, Sustanon is effective after one day and, based on the mixed in decanoates, remains active for 3-4 weeks. Sustanon has a distinct androgenic effect which is coupled with a strong anabolic effect. Therefore it is well suited to build up strength and mass. A rapid increase in body strength and an even increase in body weight occur. Athletes who use Sustanon report a solid muscle growth since it results in less water retention and also aromatizes less than either testosterone enanthate or cypionate. Indeed many bodybuilders who use testosterone and fight against distinct water retention and an elevated estrogen level prefer Sustanon over other long-acting depot testosterones.
It is further noticed that Sustanon is also effective when relatively low doses are given to well advanced athletes- It is interesting to note that when Sustanon is given to athletes who have already used this compound in the same or lower doses, it leads to similar good results as during the previous intake. Sustanon is usually injected at least once a week, which can be stretched up to 10 days. The dosage in bodybuilding and powerlifting ranges from 250 mg every 14 days up to 1000 mg or more per day. Since such high dosages are not recommended-and fortunately are also not taken in most cases-the rule is 250-1000 mg/week. A dosage of 500 mg/week is completely sufficient for most, and can often be reduced to 250-mg/ week by combining Sustanon with an oral steroid. Sustanon is well tolerated as a basic steroid during treatment which stimulates the regeneration, gives the athlete a sufficient "kick" for intense training units, and next to the already mentioned advantage-rapid strength increase and solid muscle gain distinguishes itself also by its compatibility. In order to gain mass fast Sustanon is often combined with Deca-Durabolin, Dianabol or Anadrol while athletes who are more into quality prefer combining it with Parabolan, Winstrol, Oxandrolone or Primobolan.
Although Sustanon does not aromatize excessively when taken in a reasonable dosage many people, in addition, also take an antiestrogen such as Nolvadex and/or Proviron to prevent possible estrogen-linked side effects. Since Sustanon suppresses the endogenous testosterone production the intake of HCG and Clomid must be considered after six weeks or at the end of treatment. It is recommended that women not take depot testosterones since the androgen level would strongly increase and virilization symptoms could result. Despite this, it is not uncommon for female competing athletes in the higher weight classes to take testosterone since it helps in remaining "competitive." Women who use "Testo" or who would like to try it should limit its use to either only testosterone propionate or inject a maximum of 250 mg Sustanon every 10-14 days over a period of no longer than six weeks. At this point we would like to emphasize once more that steroid novices should stay away from all testosterone compounds since, at this time, they simply do not need them. The side effects of Sustanon are similar to those of Testosterone enanthate (see also Testosterone enanthate) only that they are usu-ally less frequent and less severe. Depending on the predisposition and dosage, the user can experience the usual androgenic-linked side effects such as acne, aggressiveness, sexual overstimulation, oily skin, accelerated hair loss, and reduced production of the body's own hormones. Water retention and gynecomastia are usually within limits with the "Sustas" or are not as massive as with enanthate and cypionate. Liver damage is unlikely with Sustanon (see Test-osterone enanthate); however, in very high dosages, elevated liver values can occur which, after discontinuing use of the compound, usually go back to normal. The fact that the liver is a very efficient organ and able to cope well with higher quantities of testosterone is confirmed in the book Doping-verbotene Arzneimittel im Sport by Dirk Clasing and Manfred Donike. On page 54 the authors state: "The liver is able to metabolize an almost unlimited amount of testosterone (2 g of rat liver are able to break down 100 mg/day of testosterone). "
Sustanon is well distributed on the black market and readily available. It is difficult to find the less frequently available original "Susta. " On the black market mostly the Russian or Indian 5ustanon 250 is sold. The Indian Sustanon 250 is manufactured in Calcutta, India, by Organon and officially destined for export to Russia. Through Czechoslovakia, however, large quantities of this original Sustanon 250 are smuggled to Europe and the U.S. The Russian Sustanon 250 comes in a plastic film; printed in blue ink on the back are the name of the compound, the manufacturer, and the included substances. This imprint is either stamped on aluminum foil or on white paper. Five ampules are combined in one strip whereas each ampule is packaged individually. Original Sustanon 250 usually costs S 12 - 18 per ampule on the black market and is certainly worth the price. In the meantime there are also several fakes of the Russian version which, however, can be easily identified by the rounded corners of the label. The originals always have a label with sharp corners.
Newbies Research Guide reference
Sustanon 250 is an oil-based injectable containing four different testosterone compounds: testosterone propionate, 30 mg; testosterone phenylpropionate, 60 mg; testosterone isocaproate, 60mg; and testosterone decanoate, 100 mg. The mixture of the testosterones are time-released to provide an immediate effect while still remaining active in the body for up to a month. As with other testosterones, Sustanon is an androgenic steroid with a pronounced anabolic effect. Therefore, athletes commonly use Sustanon to put on mass and size while increasing strength. However, unlike other testosterone compounds such as cypionate and enanthate, the use of Sustanon leads to less water retention and estrogenic side effects. This characteristic is extremely beneficial to bodybuilders who suffer from gynecomastia yet still seek the powerful anabolic effect of an injectable testosterone. The decreased water retention also makes Sustanon a desirable steroid for bodybuilders and athletes interested in cutting up or building a solid foundation of quality mass. Dosages of Sustanon range from 250 mg every other week, up to 2000 mg or more per week. These dosages seem to be the extremes. A more common dosage would range from 250 mg to 1000 mg per week. Although Sustanon remains active for up to a month, injections should be taken at least once a week to keep testosterone levels stable. A steroid novice can expect to gain about 20 pounds within a couple of months by using only 250 mg of Sustanon a week. More advanced athletes will obviously need higher dosages to obtain the desired effect. Sustanon is a fairly safe steroid, but in high dosages, some athletes may experience side effects due to an elevated estrogen level. With dosages exceeding 1000 mg a week, it is probably wise to use an antiestrogen such as Nolvadex(tamoxifen citrate) or Proviron(mesterolone). The use of Sustanon will suppress natural testosterone production, so the use of HCG(human chorionic gonadotropin) or Clomid(clomiphene citrate) may be appropriate at the end of a cycle. Sustanon 250 is a good base steroid to use in a stack.
Athletes interested in rapid size and strength gains find that Sustanon stacks extremely well with orals such as Anadrol(oxymetholone) and Dianabol(methandrostenlone). On the other hand, Sustanon also stacks well with Parabolan(trenbolone hexahydrobencylcarbonate), Masteron(drostanolone propionate), and Winstrol(stanozolol) for athletes seeking the hard, ripped look. Sustanon 250 is quite abundant on the US black market. One of the more common versions is the Russian Sustanon 250 manufactured in India. Thousands of these amps are smuggled into the East Coast of the United States where theyare then made readily available to bodybuilders. Average price is around $15-$20 an amp, but prices as low as $5 an amp are available to some individuals who can purchase the amps as soon as they come ashore. The Russian Sustanon comes in plastic strips of five covered with a white paper and imprinted with blue ink. More recent lots of Russia Sustanon have the expiration date printed numerous times in purple ink going lengthwise in a line across the strip of five ampules. The ampules have a white paper label imprinted with blue ink. Don’t be surprised if the labels are crooked or peel off easily. The labels on Russian Sustanon are commonly glued on crooked, and should peel off, but not in one piece. Also, don’t be alarmed if the amps come loose without the plastic strip. The plastic strip is often thrown away to make it easier to smuggle the amps into the country. There is little need to worry about the legitimacy of Russian Sustanon. The World Anabolic Review mentions a counterfeit with rounded corners on the label, but this fake is rarely seen on the US black market.
Another popular version of Sustanon is the Sostenon 250 rediject manufactured by Organon in Mexico. The redijects are very common to the southern region of the United States because they are frequently smuggled over the border after being purchased in Mexican pharmacies. The price for a Sostenon rediject is about $8 in Mexico. In the United States, they are often sold for $20 a piece. Each Sostenon 250 rediject comes packaged in a plastic tray with a foil covering.The World Anabolic Review shows a picture of a rediject with the needle attached. This picture is outdated because Organon recently began manufacturing the Sostenon 250 redijects without the needle attached. The redijects are often favored by many because of their difficulty to counterfeit. However, recently, bodybuilders have complained about some underdosed redijects circulating on the black market in Texas. Fortunately, these underdosed redijects do not seem to be widespread. In the meantime, the chances of getting a fake rediject are still very slim. Less common, but still seen on the US black market are the European versions of Sustanon from countries like Italy, Portugal, and England. All of these amps are scored and have a white label that is difficult to peel off.The amps and boxes should have the lot number and expiration dated stamped on it. Durateston, the brand name Organon uses in Brazil is also commonly
seen in the U.S.
Wlliam Llewellyn (2011) - Anabolics
L. Rea (2002) - Chemical Muscle Enhancement Bodybuilders Desk Reference
Anabolic Steroid Guide
Newbies Research Guide