Normethandrolone was first described in 1954. Shortly after, it was developed into a medicine by Organon (now Merck/MSD), which introduced it under the Orgasterone brand name in Belgium and Switzerland, and as Orgasteron in the Netherlands. This steroid had also been sold by other manufacturers in various parts of Europe as Methalutin, Lutenin, and Matdonal. Although a simple oral methylated nandrolone, with strong properties as an anabolic steroid, normethandrolone exhibits such strong progestational activity that it was marketed as an oral progestin. Its anabolic effects were more looked at as secondary applications for the drug, and accounted for very little medical interest. It was also mainly sold under the trivial name methylestrenolone, which again seems to visibly separate the drug from the anabolic steroid category.
Given the unobvious naming and unrelated marketing of normethandrolone, it was ultimately given very little interest by athletes. Even during the 1960's, a time when many new and exotic agents were appearing on the black market, normethandrolone was essentially unheard of. The various normethandrolone preparations soon began drying up, as newer and more targeted oral progestins became available to clinicians. The drug quietly disappeared from the various international markets before bodybuilders ever made any type of substantial connection with it. Normethandrolone is now discontinued worldwide. Note that in spite of its current obscurity in the U.S., normethandrolone was added to the Federal controlled substances laws in 2004 as a schedule III anabolic steroid.
How Orgasteron is Supplied
Normethandrolone is no longer available as a prescription drug product.
Structural Characteristics of Orgasteron
Normethandrolone is a modified form of nandrolone. It differs by the addition of a methyl group at carbon 17-alpha to protect the hormone during oral administration.
Orgasteron Side Effects (Estrogenic)
Normethandrolone is aromatized by the body, and converts to a synthetic estrogen with a high level of biological activity (17alpha-methyl-estradiol). As a result, it is a highly estrogenic steroid. Gynecomastia is often a concern during treatment, and may present itself quite early into a cycle (particularly when higher doses are used). At the same time water retention can become a problem, causing a notable loss of muscle definition as both subcutaneous water retention and fat levels build. Sensitive individuals may want to keep the estrogen under control with the addition of an anti-estrogen such as Nolvadex®. One may alternately use an aromatase inhibitor like Arimidex® (anastrozole), which is a more effective remedy for estrogen control. Aromatase inhibitors, however,can be quite expensive in comparison to standard estrogen maintenance therapies, and may also have negative effects on blood lipids.
It is also of note that normethandrolone has very strong activity as a progestin in the body. In fact, it was assayed to be more active than progesterone itself. Studies usually refer to this agent as a progestogenic (progestational) compound with anabolic action, not directly as an anabofic/androgenic steroid. The side effects associated with progesterone are similar to those of estrogen, including negative feedback inhibition of testosterone production and enhanced rate of fat storage. Progestins also augment the stimulatory effect of estrogens on mammary tissue growth. There appears to be a strong synergy between these two hormones here, such that gynecomastia might even occur with the help of progestins without excessive estrogen levels being present. The use of an anti-estrogen, which inhibits the estrogenic component of this disorder, may be sufficient to mitigate gynecomastia caused by normethandrolone.
Orgasteron Side Effects (Androgenic)
Although classified as an anabolic steroid, androgenic side effects are still possible with this substance. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Individuals sensitive to the androgenic effects of this steroid may find a milder anabolic such as Deca-Durabolin® to be more comfortable. Women are additionally warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture,facial hair growth, and clitoral enlargement.
Note that in androgen-responsive target tissues such as the skin, scalp, and prostate, the relative androgenicity of normethandrolone is reduced by its reduction to dihydronormethandrolone. The 5-alpha reductase enzyme is responsible for this metabolism.The concurrent use of a 5-alpha reductase inhibitor such as finasteride or dutasteride will interfere with site-specific reduction of normethandrolone action, considerably increasing the tendency of the drug to produce androgenic side effects. Reductase inhibitors should be avoided with this steroid if maintaining low relative androgenicity is desired.
Orgasteron Side Effects (Hepatotoxicity)
Normethandrolone is a cl 7-alpha alkylated compound. This alteration protects the drug from deactivation by the liver, allowing a very high percentage of the drug entry into the bloodstream following oral administration. 0 7-alpha alkylated anabolic/androgenic steroids can be hepatotoxic. Prolonged or high exposure may result in liver damage. In rare instances life-threatening dysfunction may develop. It is advisable to visit a physician periodically during each cycle to monitor liver function and overall health. Intake of cl 7-alpha alkylated steroids is commonly limited to 6-8 weeks, in an effort to avoid escalating liver strain. Jaundice (bile duct obstruction) was reported as early as 1958 with this steroid, so this possibility definitely should not be disregarded. Severe liver complications are rare given the periodic nature' in which most people use oral anabolic/androgenic steroids, although cannot be excluded with this steroid, especially with high doses and/or prolonged administration periods.
Orgasteron Side Effects (Cardiovascular)
Anabolic/androgenic steroids can have deleterious effects on serum cholesterol.This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant bn the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Normethandrolone has a strong effect on the hepatic management of cholesterol due to its structural resistance to liver breakdown and route of administration. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.
To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.
Orgasteron Side Effects (Testosterone Suppression)
All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.
Orgasteron Administration (General)
Prescribing guidelines generally advise that oral steroids can be taken with or without meals. The difference in bioavailability is generally not regarded as substantial. However, a 2016 study on newborn infants did find the absorption of oxandrolone to be significantly improved when dissolved directly in fat (MCT oil). If the diet includes considerable fat content, taking this oral steroid with meals might be more advantageous.
Orgasteron Administration (Men)
For bodybuilding purposes, this drug would typically be taken at a dosage of 10 mg to 30 mg per day, taken in cycles lasting 6 to 8 weeks. This level is sufficient for rapid gains in strength and muscle mass (bulk). This compound is used almost exclusively for bulking phases of training, as its progestational and estrogenic nature will undoubtedly work against fat loss and muscle definition when trying to cut. Used alone, one can expect to see decent gains, something perhaps in line with a Dianabol cycle, but with a seemingly more noteworthy estrogenic side to it. The high progestational and estrogenic activities of normethandrolone also make it of little value in speed and endurance sports, causing an unwanted retention of water weight.
Orgasteron Administration (Women)
When used by women for physique- or performanceenhancing purposes, a daily dosage of 2.5-10 mg is most common, taken for no longer than 4 weeks. This level is quite effective for promoting new muscle growth. Note that virilizing side effects are still possible with primarily anabolic substances, and need to be carefully monitored.
Prescription preparations containing normethandrolone are no longer available. This drug is available as a bulk material, however, so underground versions are likely.
Wlliam Llewellyn (2017) - Anabolics