Megagrisevit-Mono — clostebol acetate

Clostebol acetate is an anabolic steroid that is derived from testosterone. Clostebol is 4- chloro-testosterone, a modification that makes this steroid a low strength anabolic compound with minimal androgenic potency. This analog of testosterone is also not 17-alpha alkylated and does not aromatize, so there is little worry of water retention, gynecomastia, or liver toxicity during use. The hydrogen substitution at the 4 position does not greatly enhance the oral efficacy of this drug, however, so the injectable is much more potent on a milligram for milligram basis, and generally preferred. Although a derivative of the potent androgen testosterone, clostebol is certainly far removed from its parent steroid in action, and generally favored by athletes for its mildness, not raw power.

Brand name Megagrisevit-Mono, Clostebol acetate, Steranabol, Turinabol, Clostebol, Megagrisevit, Macrobin, Neobol, Trofodermin, Novaderm, Andris, Metylandrostendiol, Denkdiol
Androgenic 25
Anabolic 46
Standard Testosterone
Chemical Names 4-chloro-testosterone
4-chloro-androsten-3-one-17beta-ol
Estrogenic Activity none
Progestational Activity no data available (low)

Clostebol Acetate History

Clostebol acetate was first described in 1956. It was developed into a medicine in Europe, where it was sold as Steranabol (Farmitalia, Germany) and Turinabol (Jenapharm, GDR). This anabolic steroid had generally been indicated for the treatment of osteoporosis, although it has reportedly been used with success for a wide variety of ailments including anorexia and liver disease. Both oral and injectable forms of the drug were produced, although the injectable was more popularly used. Clostebol acetate was commonly used with women and the elderly in European medicine, making clear the relative mildness of this anabolic. The side effects of anabolic/androgenic steroids can be much more pronounced in these populations, so typically very weak androgens are shown to be the most tolerable here.

Although quite favorable in effect and patient comfort, clostebol acetate was never a widely successful anabolic, and saw only limited use in a small number of markets. As such, its future would be a tenuous one. The Turinabol product from Jenapharm would disappear by the reunification of Germany, and the Steranabol brand would soon be replaced with lower dosed vitamin fortified versions of the drug sold by Farmitalia under the new Megagrisevit brand name. Pharmacia would acquire Farmitalia in 1993, although for a short point thereafter Megagrisevit was still being manufactured under the Pharmacia label. This did not last long, however, and Pharmacia eventually tightened up its line and removed this steroid from its offerings. Clostebol acetate had also appeared for some time in Japan, sold as Macrobin by the firm Teikoku, but this product too has since been discontinued.

Although the more functional injectable preparations of this steroid are off the market, clostebol acetate is still manufactured in a number of dermal preparations. The most recognizable such product has been Alfa-Trofodermin from Italy, although it has also been sold in such products as Neobol (Mexico), Trofodermin (Chile, Brazil), and Novaderm (Brazil). Dermal preparations of clostebol acetate are generally used to treat ulcers and wounds, and often include some neomycin to help accelerate healing. The doses of steroid used in these products is generally very small, however, and, combined with poor systemic delivery, are not of much use to athletes. In addition, this steroid has even been included in certain ophthalmologic solutions, which are even less practical to use for performanceenhancing purposes, and of less interest. Given that Megagrisevit was the last remaining effective oral or injectable steroid product to contain clostebol acetate, this drug is now essentially a defunct item as far as the athletic use of steroids are concerned.

How is Clostebol Acetate Supplied

Clostebol acetate is no longer available as a commercial oral or injectable agent. When produced (Steranabol) it contained 20 mg/ml of steroid in a 2 mL glass ampule or 15 mg per tablet.

Structural Characteristics of Clostebol Acetate

Clostebol is a modified form of testosterone. It differs by the introduction of a hydroxyl group at carbon 4, which inhibits aromatization and reduces relative steroid androgenicity. Clostebol acetate contains clostebol modified with the addition of carboxylic acid ester (acetic acid) at the 17-beta hydroxyl group, so that the free steroid is released more slowly from the area of injection.

Clostebol Acetate Side Effects (Estrogenic)

Clostebol is not aromatized by the body, and is not measurably estrogenic. An anti-estrogen is not necessary when using this steroid, as gynecomastia should not be a concern even among sensitive individuals. Since estrogen is the usual culprit with water retention, clostebol instead produces a lean, quality look to the physique with no fear of excess subcutaneous fluid retention. This makes it a favorable steroid to use during cutting cycles, when water and fat retention are major concerns.

Clostebol Acetate Side Effects (Androgenic)

Although classified as an anabolic steroid, androgenic side effects are still possible with this substance. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are also warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Additionally, clostebol is not extensively metabolized by the 5-alpha reductase enzyme, so its relative androgenicity is not greatly altered by the concurrent use of finasteride or dutasteride. Note that clostebol is a steroid with low androgenic activity relative to its tissue-building actions, making the threshold for strong androgenic side effects comparably higher than with more androgenic agents such as testosterone, methandrostenolone, or fluoxymesterone.

Clostebol Acetate Side Effects (Hepatotoxicity)

Clostebol is not a c17-alpha alkylated compound, and not known to have hepatotoxic effects. Liver toxicity is unlikely.

Clostebol Acetate Side Effects (Cardiovascular)

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Clostebol should have a stronger negative effect on the hepatic management of cholesterol than testosterone or nandrolone due to its non-aromatizable nature, but a much weaker impact than c-17 alpha alkylated steroids. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.

To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

Clostebol Acetate Side Effects (Testosterone Suppression)

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.

Clostebol Acetate Administration (Men)

Clostebol acetate is generally used in clinical doses of 30 mg per week by injection or 15 mg 2-3 times per day orally. The drug is administered for 3 consecutive weeks, followed by a break for 3 weeks. It is resumed at this point if indicated.

Effective doses for physique- or performance-enhancing purposes fall in the range of 100-300 mg per week, taken for 6-12 weeks. Given the fast-acting nature of acetate injectables, the weekly dosage is generally subdivided into injections given at least every third day. With the low dosage of previous commercial clostebol acetate products, daily injectable were most common. Given the lower bioavailability and higher price, oral forms of the drug were not commonly used by athletes. When administered, a daily dosage of 60-90 mg appeared to be the most common.

The anabolic effect of this drug is fairly weak, so clostebol acetate is most often utilized in combination with other steroids for a stronger effect. The general application is to use it for contest preparations with other non-aromatizing anabolics such as Winstrol or oxandrolone. Here, a daily dose of 20 mg may be added in with an average dose (20-30 mg per day) of the oral anabolic, which together should provide the user a nice muscle building effect without any water retention. The effect of clostebol would be somewhat similar to that seen with the old Primobolan acetate ampules, although Megagrisevit is somewhat weaker in effect. Some also opt to use this compound in addition with strong non-aromatizing androgens such as trenbolone, Halotestin, or mesterolone Proviron. The result in such cases can be an even more pronounced effect of muscle definition, although this will be accompanied by a much stronger set of side effects.

Clostebol Acetate Administration (Women)

Clostebol acetate is generally used in clinical doses 30 mg per week by injection or 15 mg 2- 3 times per day orally. The drug is administered for 3 consecutive weeks, followed by a break for 3 weeks. The drug is resumed at this point if indicated. Effective doses for physique- or performance-enhancing purposes fall in the range of 50-75 mg per week for the injectable, or 30-60 mg daily for the oral, taken for no longer than 6 weeks.

Clostebol Acetate Availability

Clostebol acetate is no longer available as a prescription agent at this time, and is unavailable on the black market.

Bodybuilders reference

For many whom had used Primabolan acetate injections in the past with good results during dieting, this steroid stacked with a higher androgenic drug such as Parabolan or Masteron was reported to be a great replacement. The drug itself is fairly anabolic and only a small androgenic quality exists. It was not noted as liver toxic nor have any users reported water retention or gyno. This is probably due to low dosages and high prices. However, the brief half- life provided benefits for women and tested events.

Anabolic Steroid Guide reference

Megagrisevit is an unusual steroid which has several characteris-tics. In addition to the substance clostebole acetate it also contains the two vitamins B6 and B12. The vitamin B12 is present as cyanocobalamin in the amount of 100 mcg per dragee and 2500 mcg per 1. 5 ml ampule. The chemical denomination for the vitamin B6 is pyridoxinhydrochloride and is included in a dragee with a strength of 5 0 mg while the 1. 5 ml ampule contains only 10 mg. it is also noted that in the injectable Megagrisevit both vitamins are included separately so that the red 1.5 ml vitamin ampule must be mixed with the 1.5 ml steroid injection vial prior to injection.

The main effect of Megagrisevit consists of stimulating the protein synthesis and leading to a positive nitrogen balance. It has a pre-dominantly anabolic effect which is combined with a very weak and subliminal, androgenic residual effect. "This all sounds great, some of you will say but, unfortunately it must also be noted that the anabolic effect of this compound is also not very strong. No large strength and muscle gains can be obtained with Megagrisevit but one should not immediately discard this remedy since, when used properly, it is interesting for bodybuilders. The dragees are not recommended for bodybuilders since their effect is weak, so in the following we will exclusively discuss the injectable version. Also in this context we would like to recommend in the beginning that you do not use the red ampule with the vitamin cocktail. The vitamin injection might indeed increase the appetite and in some cases lead to an improved psychological well-being but it has the disadvantage that, together with a steroid in injection, too large an injection volume j will accumulate in the body if the athlete injects the required steroid amount. It must also be considered that a high amount of B 12 and B6 will not necessarily improve performance. What remains then, is a 1.5 ml injection vial with a milky suspension that is really inter-esting. All those of you who have absolute confidence in the 20 mg Primobolanacetat ampules and bemoaned the day when they were taken off the market will find a potent substitute in this 1.5 ml injection vial. The substance clostebole acetate is dissolved in water, has a low half-life time, does not aromatize, does not retain water, and is non-toxic. It is, however, still an excellent steroid when pre-paring for a competition. Athletes normally use two 1.5 ml vials per day which can be combined into one large 3 ml injection, equal to a daily intake of 20 mg of clostebole acetate. Women also achieve remarkable results and inject the same amount every second day.

As the only steroid used during a diet phase Megagrisevit certainly is too weak; however, in combination with the stronger androgenic steroids such as Parabolan, Masteron, or Testosterone propionate it has effects similar to the old Primoacetat ampules. But there is more. Megagrisevit is not liver-toxic and in these dosage s rarely has side effects. Even women have few virilization symptoms. Package sizes of 3 inj. vials (price approx. $30) and 10 inj. vials (price approx. $85). The largest disadvantage, as can be readily recognized, is the high cost one would have to pay if injecting two vials per day There are currently no fakes of this compound.

Newbies Research Guide reference

Megagrisevit is an unusual steriod which has several characteristics. In addition to the substance clostebole acetate it also contains the two vitamins B6 and B12. The vitamin B12 is present as cyanocobalamin in the amount of 100 mcg per dragee and 2500 mcg per 1.5 ml ampule. The chemical denomination for the vitamin B6 is pyridoxinhydrochloride and is included in a dragee with a strength of 50 mg while the 1.5 ml ampule contains only 10 mg. It is also noted that in the injectable Megagrisevit both vitamins are included separately so that the red 1.5 ml vitamin ampule must be mixed with the 1.5 ml steroid injection vial prior to injection. The main effect of Megagrisevit consists of stimulating the protein synthesis and leading to a positive nitrogen balance. It has a predominantly anabolic effect
which is combined with a very weak and sublimlnal, androgenic residual effect. “This all sounds great” some of you will say but, unfortunately it must also be noted that the anabolic effect of this compound is also not very strong. No large strength and muscle gains can be obtained with Megagrisevit but one should not immediately discard this remedy since, when used properly, it is interesting for bodybuilders. The dragees are not recommended for bodybuilders since their effect is weak, so in the following we will exclusively discuss the injectable version. Also in this context we would like to recommend in the beginning that you do not use the red ampule with the vitamin cocktail. The vitamin injection might indeed increase the appetite and in some cases lead to an improved psychological well-being but it has the disadvantage that, together with a steroid injection, too large an injection volume will accumulate in the body if the athlete injects the required steroid amount. It must also be considered that a high amount of B 12 and B6 will not necessarily improve performance. What remains then, is a 1.5 ml injection vial with a milky suspension that is really interesting. All those of you who have absolute confidence in the 20 mg Primobolanacetat ampules and bemoaned the day when they were taken off the market will find a potent substitute in this 1.5 ml injection vial. The substance clostebole acetate is dissolved in water, has a low half-life time, does not aromatize, does not retain water, and is non-toxic. It is, however, still an excellent steroid when preparing for
a competition. Athletes normally use two 1.5 ml vials per day which can be combined into one large 3 ml injection, equal to a daily intake of 20 mg of clostebole acetate. Women also achieve remarkable results and inject the same amount every second day. As the only steroid used during a diet phase Megagrisevit certainly is too weak; however, in combination with the stronger androgenic steroids such as Parabolan, Masteron, or Testosterone propionate it has effects similar to the old Primoacetat am’ pules. But there is more. Megagrisevit is not liver-toxic and in these dosages rarely has side effects. Even women have few virilization symptoms. It is also one of the few steroids which is still manufactured in Germany and available in German pharmacies with a prescription so that shortages are uniikely~ Since most people do not know the benefits offered by Megagrisevit, the demand, in our experience, is so low that one wo~~t find it on the U.S. black market. Megagrisevit is available in German pharmacies in package sizes of 3 inj. vials (price approx. $30) and 10 inj. vials (price approx. $85) The prices are taken from the German Red List 1995. The largest disadvantage, as can be readily recognized, is the high cost one would have to pay if injecting two vials per day There are currently no fakes of this compound.

References

Wlliam Llewellyn (2011) - Anabolics
L. Rea (2002) - Chemical Muscle Enhancement Bodybuilders Desk Reference
Anabolic Steroid Guide
Newbies Research Guide

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