Madol — desoxymethyltestosterone

Madol (desoxymethyltestosterone; also known as DMT) is a potent synthetic oral anabolic steroid. Desoxymethyltestosterone is thought of as a cousin to methyltestosterone, although the association between the two steroids is very loose. The unique thing about desoxymethyltestosterone is that it is structurally a 2-ene compound, lacking the 3-keto group present on most commercial anabolic steroids. This lack of a 3-keto group, however, does not mean desoxymethyltestosterone is a weak compound. Quite the contrary, it is an exceedingly potent oral steroid. According to the standard rat assays, desoxymethyltestosterone exceeds methyltestosterone in oral potency by a factor of 12. At the same time, its androgenicity is recorded to be only 87% higher, giving desoxymethyltestosterone an extremely favorable anabolic to androgenic ratio (measured to be nearly 6.5:1). The resulting steroid is considerably different than methyltestosterone, a drug which is both significantly weaker mg for mg than desoxymethyltestosterone, and possesses a much more formidable androgenic component.

Brand name Madol, Desoxymethyltestosterone
Androgenic 187
Anabolic 1,200
Standard Methyltestosterone (oral)
Chemical Names 17a-methyl-17b-hydroxy-5a-androst-2-ene
Estrogenic Activity none
Progestational Activity no data available

Madol History

Desoxymethyltestosterone was first described in 1963. This agent was never made available as a commercial prescription drug product, and saw only limited investigation in animals during the mid-1960's before disappearing into research obscurity. This agent remained hidden in the library bookshelves for decades, until reemerging in 2005 as a new "designer steroid" of interest to international sports doping officials. This was due to the confiscation of a sample of DMT at the Canadian border in December of 2003, where it was found in the possession of Canadian sprinter Derek Dueck during a routine vehicle inspection. The DMT sample remained nameless in a Customs warehouse for over a year, until officials from the World Anti-Doping Agency (WADA) finally had it tested and identified. Desoxymethyltestosterone is only the third never commercially marketed anabolic steroid found to be in use by athletes, following norbolethone and THG.

Although at one point DMT could have been considered an effective and "invisible" designer steroid for use while competing in drug-tested sports, this is no longer the case. The UCLA Olympic Laboratory was successful in its quest to outline methods for detecting desoxymethyltestosterone in the urine, and these methods have been made available to all Olympic drug-testing labs. They have also been published, and as such are available to any other agency that wants to take an interest in its detection as well. Any sport that has its athletes' urine samples analyzed at an accredited laboratory will likely be checking for DMT at this point. Still, it is an oral steroid, and likely most metabolites are cleared from the body within a few weeks of stopping its use (not unlike most oral steroids).

Desoxymethyltestosterone was never sold as a commercial prescription anabolic steroid; however, it did appear on the sports nutrition market in 2005 under the brand name ErgoMax LMG (Lean Mass Generator). It was subsequently made available under many other brand names, and for quite some time was highly popular in the United States. The FDA began taking action against manufacturers of the compound in 2009, and all such compounds should have been withdrawal from market since. Note that Madol was added to the U.S. controlled substances list in January of 2010.

How is Madol Supplied

Desoxymethyltestosterone is not available as a prescription drug product.

Structural Characteristics of Madol

Desoxymethyltestosterone is a modified form of dihydrotestosterone. It differs by 1) the addition of a methyl group at carbon 17-alpha, which helps protect the hormone during oral administration, 2) the introduction of a double bond between carbons 2 and 3 (2-ene) and 3) the removal of the 3-keto group (des-oxy). The latter two modifications greatly enhance the anabolic and relative biological activity of the steroid, partly by preventing the reduction of DMT to inactive 3-hydroxysteroid metabolites.

Madol Side Effects (Estrogenic)

Desoxymethyltestosterone is not aromatized by the body, and is not known to be measurably estrogenic or progestational. An anti-estrogen should not be necessary when using this steroid. Since estrogen is the usual culprit with water retention, this steroid instead tends to produces a lean, quality look to the physique for most users. This makes it a favorable steroid to use during cutting cycles, when water and fat retention are major concerns. Note that some sensitive individuals do report estrogen-like side effects from this steroid, which suggests that it may have some low level of estrogen or progesterone receptor binding.

Madol Side Effects (Androgenic)

Although desoxymethyltestosterone is classified as an anabolic steroid, androgenic side effects are still possible with this substance. These may include bouts of oily skin, acne, and body/facial hair growth. Higher doses are more likely to cause such side effects. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are additionally warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Desoxymethyltestosterone is unaffected by the 5-alpha reductase enzyme, so its relative androgenicity is not affected by the concurrent use of finasteride or dutasteride.

Madol Side Effects (Hepatotoxicity)

Desoxymethyltestosterone is a cl 7-alpha alkylated compound. This alteration protects the drug from deactivation by the liver, allowing a very high percentage of the drug entry into the bloodstream following oral administration. Cl 7-alpha alkylated anabolic/androgenic steroids can be hepatotoxic. Prolonged or high exposure may result in liver damage. In rare instances life-threatening dysfunction may develop. It is advisable to visit a physician periodically during each cycle to monitor liver function and overall health. Intake of cl 7-alpha alkylated steroids is commonly limited to 6-8 weeks, in an effort to avoid escalating liver strain.

The use of a liver detoxification supplement such as Liver Stabil, Liv-52, or Essentiale Forte is advised while taking any hepatotoxic anabolic/androgenic steroids.

Madol Side Effects (Cardiovascular)

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Desoxymethyltestosterone has a strong effect on the hepatic management of cholesterol due to its non-aromatizable nature, structural resistance to liver breakdown, and route of administration. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.

To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

Madol Side Effects (Testosterone Suppression)

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.

Madol Administration (General)

Prescribing guidelines generally advise that oral steroids can be taken with or without meals. The difference in bioavailability is generally not regarded as substantial. However, a 2016 study on newborn infants did find the absorption of oxandrolone to be significantly improved when dissolved directly in fat (MCT oil). If the diet includes considerable fat content, taking this oral steroid with meals might be more advantageous.

Madol Administration (Men)

Desoxymethyltestosterone was never approved for use in humans; actual prescribing guidelines are unavailable. In the athletic arena, an effective oral daily dosage would fall in the range of 5-15 mg, taken in cycles lasting no more than 6-8 weeks to minimize hepatotoxicity. This level is sufficient for measurable increases in lean muscle mass and strength. Note that a dosage of 5-15 mg per day could relate to as much as 10-30 mg when using an impure "supplement" product containing a mixture of DMT and its isomers. Desoxymethyltestosterone is considered a very versatile steroid, and while it is most ideally used during cutting phases of training, is potent enough to stack with other agents for bulking purposes as well.

Madol Administration (Women)

Desoxymethyltestosterone was never approved for use in humans; actual prescribing guidelines are unavailable. In the athletic arena, an effective oral daily dosage would fall in the range of 1 -2mg, taken in cycles lasting no more than 4-6 weeks to minimize the impact of DMT's hepatotoxicity and virilizing activities.

Madol Availability

Desoxymethyltestosterone is only available in underground or black market preparations.

References

Wlliam Llewellyn (2017) - Anabolics

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