Fluoxymesterone was first described in 1956. It was assayed that same year, and shown to possess approximately 20 times the anabolic potency of methyltestosterone, possessing up to 5 times greater anabolic and androgenic potency than methyltestosterone. Early prescribing guidelines recommended its use in both sexes for the promotion of lean tissue repair and growth following such conditions as burns, delayed healing of fractures, chronic malnutrition, debilitating diseases, convalescence, paraplegia, and catabolism induced by long-term administration of cortisone. It was also used in males to treat insufficient androgen levels, and in women to treat abnormal bleeding in the uterus and advanced breast cancer.
By the mid-1970’s, the FDA had been granted much more control over the U.S. drug market. One of the first major changes with steroid medicine came when the FDA required strong substantiation for each potential use of a drug. The prescribing guidelines for fluoxymesterone were soon refined to state that the drug was “effective” for treating various forms of androgen deficiency in males, and reducing the severity of postpartum breast pain and treating androgen-responsive inoperable breast cancer in females.
It was also listed as “probably effective” in treating postmenopausal osteoporosis. Current prescribing guidelines for fluoxymesterone list only the uses of treating androgen deficiency in males and breast cancer in females. In recent years, fluoxymesterone has become viewed more and more as a controversial medication in the eyes of most clinicians. Its hepatotoxicity and potential negative impact of lipids and cardiovascular risk factors are often cited as reasons for avoiding the use of this agent in otherwise healthy males for treating androgen insufficiency. Today, testosterone preparations (injections, gels, patches, implants, etc.) are preferred for this purpose, and they supplement the same androgens missing from the body (testosterone, DHT), not more toxic synthetic derivatives. Fluoxymesterone remains for sale in the U.S. as a generic drug only. It remains available in only limited supply outside of the United States.
How is Fluoxymesterone Supplied
Fluoxymesterone is available in select human drug markets. Composition and dosage may vary by country and manufacturer,although generally contain 2mg, 2.5 mg, 5 mg, or 10 mg per tablet.
Structural Characteristics of Fluoxymesterone
Fluoxymesterone is a modified form of testosterone. It differs by 1) the addition of a methyl group at carbon 17-alpha, which helps protect the hormone during oral administration, 2) the group introduction of a fluoro group at carbon 9 (alpha) and 3) the attachment of a hydroxyl group at carbon 11 (beta), which inhibits steroid aromatization. The latter two modifications also greatly enhance the androgenic and relative biological activity of the steroid over 17-alpha methyltestosterone.
Fluoxymesterone Side Effects (Estrogenic)
Fluoxymesterone is not aromatized by the body, and is not measurably estrogenic. An antiestrogen is not necessary when using this steroid, as gynecomastia should not be a concern even among sensitive individuals. Since estrogen is the usual culprit with water retention, this steroid instead produces a lean, quality look to the physique with no fear of excess subcutaneous fluid retention. This makes it a favorable steroid to use during cutting cycles, when water and fat retention are major concerns.
Fluoxymesterone Side Effects (Androgenic)
Fluoxymesterone is classified as an androgen. Androgenic side effects are common with this substance, and may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Those genetically prone to male pattern hair loss may wish to opt for a milder, less androgenic, anabolic steroid. As a potent androgen, this steroid may also increase aggressiveness. Women are additionally warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement.
Fluoxymesterone appears to be a good substrate for the 5-alpha reductase enzyme. This is evidenced by the fact that a large number of its metabolites are found to be 5-alpha reduced androgens, which coupled with its outward androgenic nature, suggests that this steroid is converting to a much more active steroid in androgen responsive target tissues such as the skin, scalp and prostate. It may be possible to reduce the relative androgenicity of fluoxymesterone by the concurrent use of finasteride or dutasteride.
It is also of note that fluoxymesterone has been shown to possess usual androgenic properties. In human studies published back in 1961, the steroid displayed a much stronger tendency to promote phallic enlargement compared to other androgenic effects such as hair growth, libido, and changes in vocal pitch. Fluoxymesterone was offering a somewhat different androgenic profile compared to testosterone, and as such demonstrated that it was possible, at some level, to actually tailor drug effect within the broad category of androgenic action. Fluoxymesterone remains considered an androgen, but studies like the above suggest that it may not offer a complete biological equivalent to testosterone where androgenicity is concerned.
Fluoxymesterone Side Effects (Hepatotoxicity)
Fluoxymesterone is a c17-alpha alkylated compound. This alteration protects the drug from deactivation by the liver, allowing a very high percentage of the drug entry into the bloodstream following oral administration. C17-alpha alkylated anabolic/androgenic steroids can be hepatotoxic. Prolonged or high exposure may result in liver damage. In rare instances life-threatening dysfunction may develop. It is advisable to visit a physician periodically during each cycle to monitor liver function and overall health. Intake of c17-alpha alkylated steroids is commonly limited to 6-8 weeks, in an effort to avoid escalating liver strain. Studies administering 20 mg of fluoxymesterone to a group of nine male subjects for two weeks resulted in most patients (6/9) noticing abnormal sulfobromophthalein (BSP) retention, a marker of liver stress.
Fluoxymesterone Side Effects (Cardiovascular)
Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Fluoxymesterone has a strong effect on the hepatic management of cholesterol due to its structural resistance to liver breakdown and route of administration. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.
To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.
Fluoxymesterone Side Effects (Testosterone Suppression)
All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.
Studies administering 10 mg, 20 mg, or 30 mg of fluoxymesterone to nine healthy male subjects for up to 12 weeks have demonstrated the strong suppression of endogenous testosterone levels, with inconsistent effects on gonadotropin levels. Although not fully understood, fluoxymesterone is proposed to have a direct suppressive effect on testicular steroidogenesis that is not mediated by the suppression gonadotropins.
Fluoxymesterone Administration (General)
Studies have shown that taking an oral anabolic steroid with food may decrease its bioavailability. This is caused by the fat-soluble nature of steroid hormones, which can allow some of the drug to dissolve with undigested dietary fat, reducing its absorption from the gastrointestinal tract. For maximum utilization, this steroid should be taken on an empty stomach.
Fluoxymesterone Administration (Men)
To treat androgen insufficiency, early prescribing guidelines for fluoxymesterone called for a dose of 2-10 mg per day. Modern prescribing guidelines call for a daily dosage of 5-20 mg. Therapy is usually initiated at the full 20 mg dosage,which is later adjusted downward to meet the individual needs of the patient. The drug would be continued long-term unless laboratory tests (lipids, liver enzymes, etc.) or side effects contraindicate its continued use.
For physique- or performance-enhancing purposes, an effective oral daily dosage would fall in the range of 10-40 mg, taken in cycles lasting no more than 6-8 weeks to minimize hepatotoxicity. This level is sufficient for measurable increases in muscle strength, which may be accompanied by modest increases in lean muscle mass.
Fluoxymesterone is commonly used by athletes in weight-restricted sports like wrestling, powerlifting, and boxing, due to the fact that strength gained from the drug is usually not accompanied by great increases in bodyweight. When properly used, it can allow a competitor to stay within a specified weight range, yet drastically improve his performance. Fluoxymesterone is also commonly used for bodybuilding contest preparation. When the competitor has an acceptably low body fat percentage, the strong androgen level (in absence of excess estrogen) can elicit an extremely hard and defined (“ripped”) look to the muscles. The shift in androgen/estrogen ratio additionally seems to bring about a state in which the body may be more inclined to burn off excess fat and prevent new fat storage. The “hardening” effect of fluoxymesterone would, therefore, be somewhat similar to that seen with trenbolone, although it will be without the same level of mass gain.
In cutting phases, a milder anabolic such as Deca-Durabolin or Equipoise is commonly stacked with fluoxymesterone, as they provide good anabolic effect without excessive estrogen buildup. Here, fluoxymesterone provides a well-needed androgenic component, helping to promote a more solid and defined gain in muscle mass, with less interference with energy and libido, than might be obtained with a primarily anabolic agent alone. Perhaps Primobolan-Depot would be an even better choice, as with such a combination there is no buildup of estrogen, and likewise even less worry of water and fat retention. For mass, one might alternately use an injectable testosterone. A mix of 400 mg per week of testosterone enanthate and 20-30 mg daily of fluoxymesterone, for example, often provides exceptional increases in strength and lean muscle mass. A more significant level of androgenic side effects usually accompanies such a combination, however, as both compounds exhibit strong androgenic activity in the body.
Fluoxymesterone Administration (Women)
Fluoxymesterone is most often used as a secondary medication during inoperable androgensensitive breast cancer, when other therapies have failed to produce a desirable effect. The dosage used for this application is 10-40 mg per day. Virilizing effects are common at doses of only 10-15 mg per day in these patients.
Fluoxymesterone is not recommended for women for physique- or performance-enhancing purposes due to its strong androgenic nature and tendency to produce virilizing side effects.
Pharmaceutical preparations containing fluoxymesterone remain scarce. The drug has largely associated with western medical markets, where it has been falling out of favor for most clinical application. The bulk of the supply presently comes from underground steroid manufacturers and export-only products. In reviewing some of the remaining products and changes in the global pharmaceutical market, we have made the following observations.
Currently, the most popular item found on the black market is the Stenox brand from Mexico, which is sold in boxes of 20 tablets. Note that the dosage of these tablets is only 2.5 mg.
Fluoxymesterone remains available in the U.S. as a generic drug by USL Pharma. It is available in a 10 mg tablet only.
Balkan Pharmaceuticals (Moldova) makes the product Halotest. It is prepared in 2 mg, 5 mg, and 10 mg tablets, with 20 tablets contained in each foil and plastic strip.
Halotestin is produced by Swiss Remedies and available across Europe. Due to numerous fakes of this product, Swiss Remedies offers a convenient online product checker.
Magnus Pharmaceuticals makes the product Halotestin primarily for the EU and UK markets. Due to fake products appearing on the market, Magnus offers an online checker that lets steroid users verify their product originality.
Halotestin is an oral c17-alfa-alkylated AAS that provided good strength gains and low-moderate anabolic qualities. This means that the drug alone failed to provide significant muscle mass gains. Obviously power lifters seeking improved strength while maintaining a certain body weight liked this drug. Bodybuilders used Halotestin to improve muscle hardness during the last 4-6 weeks of dieting before competition. Since this drug does not aromatize and water retention seldom results from its use, this drug worked quite well for this purpose. However, when stacked with an injectable anabolic prone drug such as EQUIPOISE, DECA, or ANADUR, for example, the high increase in strength gains realized from Halotestin were well transformed into quite respectable lean muscle mass gains. Normally males ingested 20-40 mg daily divided into 2-3 even dosages for 3-6 weeks.
Though gyno or water retention is unlikely to occur from the use of Halotestin, there are several side effects. Since this drug is an alteration of Methyltestosterone (with a higher androgenic/lower anabolic effect) and a c17-alkylated steroid, it is quite hard on the liver. Nose bleeds, headaches, stomach aches, and acne are some of the reported side effects. Users seldom reported profitable use that extended beyond 4-6 weeks.
Anabolic Steroid Guide reference
Halotestin is an oral steroid. Its fluoxymesterone substance is a precursor of methyltestosterone which, through changes in the chemical structure, was made much more androgenic than test-osterone. The anabolic component of Halotestin is only slightly pronounced. Based on its characteristics Halotestin is used mainly when the athlete is more interested in a strength buildup rather than in a muscle gain. Powerlifters and weightlifters who must stay within a certain weight class often use Halotestin because they are primarily interested in a strength gain without adding body weight. In bodybuilding this drug is almost exclusively taken during preparation for a competition. With a lower body fat content Halotestin gives the bodybuilder a distinctive muscle hardness and sharpness. Although the muscle diameter does not increase, it appears more massive since the muscle den-sity is improved. The fact that a daily dose of up to 20 mg does not cause water and salt retention makes it even more desirable. During a diet, Halotestin helps the athlete get through difficult, intense training while increasing the aggressiveness of many us-ers. This is another reason why it is so popular among powerlifters, weightlifters, football players, and, in particular, boxers. The generally observed dose is normally 20-40 mg/day. Bodybuilders are usually satisfied with 20-30 mg/day while powerlifters often take 40 mg/day or more. The daily dosage is usually split into two equal amounts and taken mornings and evenings with plenty of fluids. Since the tablets are 1 7-alpha alky-lated, they can be taken during meals without any loss in effect.
Those who are tired of taking Dianabol tablets will find Halotestin an interesting alternative. In the meantime we know several body-builders who have combined Halotestin with injectable, mostly anabolic, steroid preparations such as Anadur, Deca-Durabolin, Primobolan Depot, or Equipoise. The quick strength gain induced by Halotestin can usually be turned into solid, high-quality muscle tissue by taking the above steroids. This is an ?specially welcome change for athletes who easily retain water arid have to fight against swollen breast glands. Many will be surprised at what progress can be achieved by a simple combination of 30 mg Halotestin/day and 100 mg Equipoise every two days over a four week period.
"So far, so good," you will say, but unfortunately, this is not so since Halotestin is a very toxic steroid. Besides Anadrol 50 and Methyltestosterone it is the oral steroid with the most side effects. Those who would like to try Halotestin should limit the intake to 4-6 weeks and take no more than 20-30 mg daily Fluoxymesterone puts extremely high stress on the liver and is thus potentially liver damaging. Other frequently- observed side effects are increased pro-duction of the sebaceous gland (which goes hand in hand with acne), nasal bleeding, headaches, gastrointestinal pain, and reduced pro-duction of the body's own hormones. Men become easily irritable and aggressive. Gynecomastia and high blood pressure caused by edemas do not occur with Halotestin. Do not be surprised, however, when on Halotestin's package insert you read the words "gynecomastia" and "edemas." This standard warning, due to legal provisions, is included in all strong androgenic steroids. Women should avoid Halotestin since it can cause substantol and in part irreversible virilization symptoms. One hundred 10 mg tablets cost approx. $100 on the black market.
Stenox also known as Halotestin, has an extreme androgenic effect and a very slight anabolic effect. With this combination, a person can expect a great increase in muscle hardness and strength with no real gain in size or weight. Because of the very high androgenic effect, many athletes have reported high levels of aggression making their workouts extremely intense. A common dosage of Stenox is in the range of 20-30 mg which is between 8 and 12 tablets for a 4-6 week cycle. At this level an athlete can expect massive strength gains with a very low tendency of water and salt retention. Stenox is considered to be the most toxic oral steroid and has a high rate of side effect occurrences. This fact has kept most people, especially women, away from this compound. Stenox is also very hard on the liver and should never exceed 30 mg/day. Its strong androgenic characteristics have been commonly responsible for liver damage, headaches, irritability, aggressiveness, acne, gastrointestinal pain, virilization in women, and suppression of natural hormone levels.
Newbies Research Guide reference
This is an oral steroid, which is derived from methyltestosterone. Due to its molecular structure it is very androgenic. Many athletes use this drug to attain strength or a harder look to already lean muscles. The toxicity of this drug is very high. It will not aromatise in dosages of 20mg per day or less. Aggressiveness is often increased in men who are on Halotestin; it should not be taken for more than four weeks at a time. Dosages of 10mg to 20mg daily are thought to be an ample amount.
Wlliam Llewellyn (2011) - Anabolics
L. Rea (2002) - Chemical Muscle Enhancement Bodybuilders Desk Reference
Anabolic Steroid Guide
Newbies Research Guide