Ermalone — mestanolone

Mestanolone is an oral analog of dihydrotestosterone. This steroid is a 17-alpha methylated form of this potent endogenous androgen, being essentially (in structure) to DHT what methyltestosterone is to testosterone. Overall, mestanolone has an activity profile not very dissimilar from the hormone it is derived from. For starters, like DHT, mestanolone is primarily androgenic in nature, displaying a low level of anabolic activity. Both DHT and mestanolone are also devoid of estrogenic activity, which eliminates-the chance for estrogenic side effects like water retention, fat deposition, and gynecomastia. In fact, both should be measurably anti-estrogenic in effect, inhibiting the aromatase enzyme in a competitive and dose-dependant manner. Among athletes, this drug is valued for its ability to promote pure strength gains and improved aggression and focus, with minimal gains in total bodyweight.

Brand name Ermalone, Mestanolone
Androgenic 78-254
Anabolic 107
Standard Testosterone
Chemical Names 17a-methyl-4,5a-dihydrotestosterone
Estrogenic Activity none
Progestational Activity none

Ermalone History

Dihydrotestosterone was first synthesized in 1935. Mestanolone, trivial name for the 17-alpha alkylated form of dihydrotestosterone, was produced shortly after. To spite such an old history as an investigatory agent, however, this steroid has been scarcely used in clinical medicine. The only noteworthy preparation to appear during the last forty years has been Ermalone, which was manufactured for a short period of time by Roussel Pharmaceuticals in Germany. It has since been discontinued, however. Many things probably led to the general abandonment of this steroid in the pharmaceutical industry, including an increased number of alternative agents, a lack of financial viability, and a reassessment of its tissue-building and hepatotoxic properties.

Most of the studies on mestanolone took place during the 1950's and '60's. This was a period when a great deal of drug development was taking place. Many new compounds were being introduced, and many old ones were being reassessed for potential value. Although mestanolone had been synthesized long before, the drug was seeing revitalized interest by researchers due to more recent assays showing that the agent could provide both strong androgenic and anabolic effects. For a short period of time it was believed that mestanolone would be a palatable tissue-building agent. Not long after, however, the general consensus about this agent came to be that it was an androgen, not really a strong anabolic, and that its risk profile (hepatotoxicity, lipid alterations) probably did not warrant its use over other commercial androgen preparations.

Although it had a weak history as a prescription medicine, mestanolone was one of the oldest and most-valued secrets of the East German doping machine, the infamous state- sponsored doping program of the 1970s and '80s that developed advanced systematic techniques designed to assist drug-tested athletes avoid detection. This program allowed East German athletes to evade countless urine tests and become a dominant force in Olympic sports throughout much of the Cold War era. Mestanolone was valued not for its potency as a muscle builder, but for its abilities as a pure and powerful androgen. Its effects were largely focused on the central nervous system and neuromuscular interaction. Athletes would routinely comment that while the drug would not make them huge, it was very capable of improving speed, strength, aggression, endurance, and resistance to stress. Drug tested or not, mestanolone remains intrinsically valuable today as a fast-acting oral androgen capable of providing tangible benefits to many users.

How is Ermalone Supplied

Mestanolone is no longer available as a prescription agent. When manufactured, it came in the form of an oral tablet.

Structural Characteristics of Ermalone

Mestanolone is a modified form of dihydrotestosterone. It differs by the addition of a methyl group at carbon 17-alpha, which helps protect the hormone during oral administration.

Ermalone Side Effects (Estrogenic)

Mestanolone is not aromatized by the body, and is not measurably estrogenic. An anti-estrogen is not necessary when using this steroid, as gynecomastia should not be a concern even among sensitive individuals. Note that due to its structural similarity to dihydrotestosterone, mestanolone likely also has inherent anti-estrogenic properties, competing with aromatizable substrates for binding to the aromatase enzyme.

Ermalone Side Effects (Androgenic)

Mestanolone is an androgen. Higher than normal therapeutic doses are likely to produce androgenic side effects including oily skin, acne, and body/facial hair growth. Men with a genetic predisposition for hair loss (androgenetic alopecia) may notice accelerated male pattern balding. Women are warned of the potential virilizing effects of anabolic/androgenic steroids, especially with such a strong androgen. These may include deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Note that mestanolone is unaffected by the 5-alpha reductase enzyme, so its relative androgenicity is not affected by the concurrent use of finasteride or dutasteride.

Ermalone Side Effects (Hepatotoxicity)

Mestanolone is a cl 7-alpha alkylated compound. This alteration protects the drug from deactivation by the liver, allowing a very high percentage of the drug entry into the bloodstream following oral administration. Cl 7-alpha alkylated anabolic/androgenic steroids can be hepatotoxic. Prolonged or high exposure may result in liver damage. In rare instances life-threatening dysfunction may develop. It is advisable to visit ar physician periodically during each cycle to monitor liver function and overall health. Intake of cl 7-alpha alkylated steroids is commonly limited to 6-8 weeks, in an effort to avoid escalating liver strain.

The use of a liver detoxification supplement such as Liver Stabil, Liv-52, or Essentiale Forte is advised while taking any hepatotoxic anabolic/androgenic steroids.

Ermalone Side Effects (Cardiovascular)

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Mestanolone has a strong effect on the hepatic management of cholesterol due to its non-aromatizable nature, structural resistance to liver breakdown, and route of administration. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.

To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

Ermalone Side Effects (Testosterone Suppression)

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypo'gonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.

Ermalone Administration (Men)

Effective doses for physique- or performance-enhancing purposes fall in the range of 10-20 mg per day, taken for no more than 6-8 weeks to minimize hepatic stress. At this level mestanolone should impart considerable strength gains, and may also aid in the speed performance of competitive athletes. Provided diet is adequate, this androgen should also promote fat loss, and will increase muscular definition by reducing the level of water retention.

Ermalone Administration (Women)

Mestanolone is not recommended for women for physique- or performance-enhancing purposes due to its strong androgenic nature and tendency to produce virilizing side effects.

Ermalone Availability

Mestanolone is no longer in commercial production. Several underground laboratories have released products containing the agent, however, making it available on the black market.

References

Wlliam Llewellyn (2017) - Anabolics

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