Anadur — nandrolone hexyloxyphenylpropionate

Nandrolone hexyloxyphenylpropionate is a slow-acting injectable form of the anabolic steroid nandrolone. Hexyloxyphenylpropionate, also called parahexyloxyphenylpropionate, is a fairly unusual nandrolone ester in a structural sense. It is essentially nandrolone phenylpropionate, which has been extended with a tail of one additional oxygen atom and 6 more carbons. It is the largest, and likely the slowest acting, ester of nandrolone to ever be introduced into clinical medicine. It is considerably slower acting than the popular Deca-Durabolin (nandrolone decanoate), and generally would be administered once every three to four weeks in a medical setting. Nandrolone hexyloxyphenylpropionate is no longer manufactured, but when available was favored by athletes and bodybuilders for its ability to promote slow steady gains in lean mass with low estrogenic and androgenic side effects.

Brand name Anadur, Anador, Anadurin
Androgenic 37
Anabolic 125
Standard Testosterone
Chemical Names 19-nortestosterone hexyloxyphenylpropionate
17beta-Hydroxyestra-4-en-3-one hexyloxyphenylpropionate
Estrogenic Activity low
Progestational Activity moderate

Nandrolone Hexyloxyphenylpropionate History

Nandrolone hexyloxyphenylpropionate was first described in 1960. It was developed into a medicine shortly after, and was sold mainly under the Anadur brand name in such markets as Austria, Sweden, Switzerland, Belgium, Netherlands, and Germany. Anadur persisted through the early 1990’s, and, following some mergers and acquisitions, was sold mainly by Kabi Pharmacia. Kabi would also sell the drug in France, but under the brand name Anador. Indicated uses for the drug included osteoporosis, chronic renal and intestinal disorders, and radiation and chemotherapy induced suppression of red blood cells (anemia). It was also used as a general lean-tissue-building anabolic, with certain diseased states, injury, or convalescence.

Nandrolone hexyloxyphenylpropionate was not widely distributed outside of Europe, and in spite of a long history of relative safety,would not last as a medicinal product. The 1995 merger of Kabi with Upjohn formed the company Pharmacia & Upjohn, and would soon spell the commercial end to Anadur. Pharmacia & Upjohn did continue to market the drug in Austria, but only briefly, and soon refined its offerings to eliminate all forms of nandrolone hexyloxyphenylpropionate in all countries. It is of note that this ester of nandrolone was also sold by Leo in Spain (Anadur), Lundbeck in Denmark (Anadur), Eczacibasi in Turkey (Anadur), and by Xponei in Greece (Anadurin), much under direct license with Kabi. All such preparations have since been discontinued as well, however, and nandrolone hexyloxyphenylpropionate is no longer available as a commercial medicine.

How is Nandrolone Hexyloxyphenylpropionate Supplied

Nandrolone hexyloxyphenylpropionate is no longer available as a prescription drug product. When supplied, it usually contained 25 mg/mL or 50 mg/mL of steroid dissolved in oil in a 1 mL or 2 mL ampule.

Structural Characteristics of Nandrolone Hexyloxyphenylpropionate

Nandrolone hexyloxyphenylpropionate is a modified form of nandrolone, where a carboxylic acid ester (parahexyloxyphenylpropionic acid) has been attached to the 17-beta hydroxyl group. Esterified steroids are less polar than free steroids, and are absorbed more slowly from the area of injection. Once in the bloodstream, the ester is removed to yield free (active) nandrolone. Esterified steroids are designed to prolong the window of therapeutic effect following administration, allowing for a less frequent injection schedule compared to injections of free (unesterified) steroid. Nandrolone hexyloxyphenylpropionate is designed to provide a slow release of nandrolone for up to four weeks following injection.

Nandrolone Hexyloxyphenylpropionate Side Effects (Estrogenic)

Nandrolone has a low tendency for estrogen conversion, estimated to be only about 20% of that seen with testosterone. This is because while the liver can convert nandrolone to estradiol, in other more active sites of steroid aromatization such as adipose tissue nandrolone is far less open to this process. Consequently, estrogen related side effects are a much lower concern with this drug than with testosterone. Elevated estrogen levels may still be noticed with higher dosing, however, and may cause side effects such as increased water retention, body fat gain, and gynecomastia. An anti-estrogen such as clomiphene citrate or tamoxifen citrate may be necessary to prevent estrogenic side effects if they occur. One may tamoxifen citrate may be necessary to prevent estrogenic side effects if they occur. One may alternately use an aromatase inhibitor like Arimidex (anastrozole), which more efficiently controls estrogen by preventing its synthesis. Aromatase inhibitors can be quite expensive in comparison to anti-estrogens, however, and may also have negative effects on blood lipids.

It is of note that nandrolone has some activity as a progestin in the body. Although progesterone is a c-19 steroid, removal of this group as in 19-norprogesterone creates a hormone with greater binding affinity for its corresponding receptor. Sharing this trait, many 19-nor anabolic steroids are shown to have some affinity for the progesterone receptor as well. The side effects associated with progesterone are similar to those of estrogen, including negative feedback inhibition of testosterone production and enhanced rate of fat storage. Progestins also augment the stimulatory effect of estrogens on mammary tissue growth. There appears to be a strong synergy between these two hormones here, such that gynecomastia might even occur with the help of progestins, without excessive estrogen levels. The use of an anti-estrogen, which inhibits the estrogenic component of this disorder, is often sufficient to mitigate gynecomastia caused by nandrolone.

Nandrolone Hexyloxyphenylpropionate Side Effects (Androgenic)

Although classified as an anabolic steroid, androgenic side effects are still possible with this substance, especially with higher doses. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Nandrolone is a steroid with relatively low androgenic activity relative to its tissue-building actions, making the threshold for strong androgenic side effects comparably higher than with more androgenic agents such as testosterone, methandrostenolone, or fluoxymesterone. It is also important to point out that due to its mild androgenic nature and ability to suppress endogenous testosterone, nandrolone is prone to interfering with libido in males when used without another androgen.

Note that in androgen-responsive target tissues such as the skin, scalp, and prostate, the relative androgenicity of nandrolone is reduced by its reduction to dihydronandrolone (DHN). The 5-alpha reductase enzyme is responsible for this metabolism of nandrolone. The concurrent use of a 5-alpha reductase inhibitor such as finasteride or dutasteride will interfere with site-specific reduction of nandrolone action, considerably increasing the tendency of nandrolone to produce androgenic side effects. Reductase inhibitors should be avoided with nandrolone if low androgenicity is desired.

Nandrolone Hexyloxyphenylpropionate Side Effects (Hepatotoxicity)

Nandrolone is not c-17 alpha alkylated, and not known to have hepatotoxic effects. Liver toxicity is unlikely.

Nandrolone Hexyloxyphenylpropionate Side Effects (Cardiovascular)

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Studies administering 600 mg of nandrolone decanoate per week for 10 weeks demonstrated a 26% reduction in HDL cholesterol levels. This suppression is slightly greater than that reported with an equal dose of testosterone enanthate, and is in agreement with earlier studies showing a slightly stronger negative impact on HDL/LDL ratio with nandrolone decanoate as compared to testosterone cypionate. Nandrolone injectables, however, should still have a significantly weaker impact on serum lipids than c-17 alpha alkylated agents. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.

To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

Nandrolone Hexyloxyphenylpropionate Side Effects (Testosterone Suppression)

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. For sake of comparison, studies administering 100 mg per week of nandrolone decanoate for 6 weeks have demonstrated an approximate 57% reduction in serum testosterone levels during therapy. At a dosage of 300 mg per week, this reduction reached 70%. It is believed that the progestational activity of nandrolone notably contributes to the suppression of testosterone synthesis during therapy, which can be marked in spite of a low tendency for estrogen conversion. Without the intervention of testosterone stimulating substances, testosterone levels should return to normal within 2-6 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention. The above side effects are not inclusive.

Nandrolone Hexyloxyphenylpropionate Administration (Men)

When used for physique- or performance-enhancing purposes, a dose of 200-400 mg given every week to 10 days was most common, taken in cycles eight to twelve weeks in length. This level is sufficient for most users to notice measurable gains in lean muscle mass and strength, which should be accompanied by a low level of estrogenic and androgenic activity.

When used for physique- or performance-enhancing purposes, a dosage of 50 mg per week, or 100 mg every 10-14 days, was most common. Although only slightly androgenic, women are occasionally confronted with virilization symptoms when taking this compound. Should virilizing side effects become a concern, the drug should be discontinued immediately to help prevent their permanent appearance. After a sufficient period of withdrawal, the shorter acting nandrolone Durabolin might be considered a safer (more controllable) option. This drug stays active for only several days, greatly reducing the withdrawal time if indicated.

Nandrolone Hexyloxyphenylpropionate Availability

Nandrolone hexyloxyphenylpropionate is no longer available as a prescription drug product.

Bodybuilders reference

Anadur is the longest lasting injectable Nandrolone. The use of this drug provided results similar to Deca Durabolin. Like all Nandrolones, a very high protein intake was needed during cycles as a fundamental fact. This is due to Nandrolones high anabolic effect which stimulates protein synthesis at an impressive rate. 1-2 gm of protein per LB of body weight daily was considered a good guideline. This is a very slow acting anabolic that provided slow but steady lean mass gains and some strength gains. Others (and myself) had noted that gains that were made on cycles utilizing this product tended to be retained quite well after cycles were discontinued. Another noted plus was the lack of DHT activity for those whom reported prior prostate concerns. The use of HCG or Clomid to stimulate natural testosterone production post-cycle was rare if reasonable dosages and/or short term cycles were employed. Being a Nortestosterone product, Anadur aromatizes only slightly to a less active estrogen by-product called Norestrogen. The use of anti-estrogens was seldom employed for this reason unless the drug was utilized during pre-contest protocols. If Anadur was used during a diet phase it was considered highly effective and important that an androgenic was also stacked with it due to its inability to protect against muscle loss as a normal result of restricted calories and over training. To date, I have not seen virilization effects with women athletes whom have not exceed the reported upper average dosage even after several months of use. However, any derivative of testosterone has the potential to induce virilization. Liver damage, even in high dosages, was very unlikely. In fact the product was often taken by those with liver disease.

Anabolic Steroid Guide reference

Anadur is one of many steroids which contain the compound nandrolone. Although available in many countries athletes do not use it often. Since its effect is similar to Deca-Durabolin's most people see no reason to take Anadur. This product does, however, have a few characteristics which make it different from "Deca" and therefore an interesting drug. Anadur is the longest lasting nandrolone. After only one injection the substance remains active in the body for four weeks. Anadur, above all, has an anabolic effect which stimulates the protein synthesis and, as with all nandrolones, requires a high protein intake. Anadur is not a steroid to be used to achieve rapid gains in weight and strength but is a classic, basic anabolic steroid which can be stored in the body, allowing a slow but solid muscle gain and an even strength gain. Athletes using Anadur report less water retention than with Deca. For this reason some bodybuilders prefer Anadur when preparing for a competition. It must be observed, however, that in this phase usage of Anadur should be combined with stronger androgenic steroids such as Parabolan or Testosterone propionate. Because of its slow, even, and compatible effect it is mostly used during steroid treatments which last for several months. For the most part, progress made during this period usually remains after discontinuing the product. When taking 50-100 mg every 10 days some women normally show no virilization symptoms but it has been shown that only a few weeks of such use will result in some irreversible virilization for some women. They like to combine Anadur with Winstrol tablets, Primobolan S-tablets, or Oxandrolone. Men do not have to take antiestrogens since Anadur aromatizes only lightly and only in rare cases does it lead to gynecomastia.

The side effects of Anadur are even less than those of Deca-Durabolin. Liver damage can be excluded so that it can even be taken by people with liver disease. Virilization symptoms such as acne, hoarseness, deep voice, hirsutism, and increase in libido only occur, if at all, in very sensitive women. A higher blood pressure, due to a low water and salt retention, cannot be excluded but rarely occurs. The use of testosteronestimulating compounds such as HCG or Clomid is not necessary since Anadur influences the hypothalamohypophysial testicular axis only slightly so that the endogenous testosterone production is not significantly reduced and the risk of a spermatogenic inhibition is minimal. Anadur is a very compatible steroid which improves the general condition and well-being of its user. Some athletes mention an improved psychological well being. As for the dos-age, good results can be obtained with 200 mg every 10 days. On the U.S. black market, one large ampule costs approx. $13 to $15. A U.S pharmaceutical product does not exist. The Belgian and Turkish Anadur, the French Anador, and the Greek version Anadurin are individually packed and costs approx. $10-15 per 50 mg/ampule on the black market. Insufficient availability on the black market forces athletes to use the more readily available Deca- Durabolin. Unlike Deca, there are no fakes of Anadur.

Newbies Research Guide reference

Trade names: Anador 50 mg/ml; Pharmacia FR Anadur 50 mg/ml; Kabi Pharmacia G, A, CH,O; Pharmacia B, NL, Fl, CZ Anadur 50 mg/2m1; Eczacibasi
TK Anadur 25 mg/ml; Lundbeck DK Anadur 25 mg/ml; Lundbeck DK Anadur (o.c.)25 mg/ml; Leo ES Anadurin 50 mg/ml; Xponei GR

Anadur is one of many steroids which contains the compound nandrolone. Although available in many countries athletes do not use it often. Since its effect is similar to Deca-Durabolin’s most people see no reason to take Anadur. This product does, however have a few characteristics, which make it different from “Deca” and therefore an interesting drug. Anadur is the longest lasting nandrolone. After only one injection the substance remains active in the body for four weeks. Anadur, above all, has an anabolic effect, which stimulates the protein synthesis and, as with all nandrolones, requires a high protein intake. Although almost everyone knows that during the intake of steroids more protein is needed, the effect of nandrolone depends on this requirement more than any other steroid. Although this is generally uncommon with steroid products, the consumer information on Anadur points out this fact: “During treatment with Anadur care must be taken that the patient eats a fully balanced diet with adequate protein.” In practice, it has been shown that a daily minimum amount of I - 1.5 mg/pound of body weight is required. Anadur is not a steroid to be used to achieve rapid gains in weight and strength but is a classic, basic anabolic steroid which can be stored in the body, allowing a slow but solid muscle gain and an even strength gain. Athletes using Anadur report less water retention than with Deca. For this reason some bodybuilders prefer Anadur when preparing for a competition. It must be observed, however, that in this phase usage of Anadur should be combined with stronger androgenic steroids such as Parabolan or Testosterone propionate, since the androgenic effect of Anadur is too low to pro- tect against the loss of muscle from overtraining during a diet. Because of its slow, even, and compatible effect it is mostly used during steroid treatments which last for several months. For the most part, progress made during this period usually remains after discontinuing the product. Anadur is also a suitable compound for steroid novices and female athletes. When taking 50-100 mg every 10 days women normally show no virilization symptoms and they like to combine Anadur with Wmstrol tablets, Primobolan 5-tablets, or Oxandrolone. Men do not have to take antiestrogens since Anadur aromatizes only lightly and only in rare cases does it lead to gynecomastia.

The side effects of Anadur are even less than those of Deca-Durabolin. Liver damage can be excluded so that it can even be taken by people with liver disease. Virilization symptoms such as acne, hoarseness, deep voice, hirsutism, and increase in libido only occur, if at all, in very sensitive women. A higher blood pres- sure, due to a low water and salt retention, cannot be excluded but rarely occurs. The use of testosterone-stimulating compounds such as HCG or Clomid is not necessary since Anadur influences the hypothalamohypophysial testicular axis only slightly so that the endogenous testosterone production is not significantly reduced and the risk of a spermatogenic inhibition is minimal. Anadur is a very compatible steroid, which improves the general condition and well being of its user. Some athletes mention an improved psychological well being. As for the dosage, good results can be obtained with 200 mg every 10 days. Contrary to Deca, which athletes usually inject weekly, Anadur produces extremely long effects, allowing large intervals between injections. It is inconvenient for athletes that most of them must fall back on the German or Belgian Anadur, or French Anador which requires the purchase and injection of four 50 mg ampules. Athletes who are not afraid of larger injections therefore use one large 4-ml injection every 10 days. The high price of Anadur can really frighten the athlete. On the U.S. black market, one large ampule costs approx. $13 to $15. A U.S pharmaceutical product does not exist. The Belgian and Turkish Anadur, the French Anador, and the Greek version Anadurin are individually packed and costs approx. $10-I5 per 50mg/ampule on the black market.

References

Wlliam Llewellyn (2011) - Anabolics
L. Rea (2002) - Chemical Muscle Enhancement Bodybuilders Desk Reference
Anabolic Steroid Guide
Newbies Research Guide

Back to Steroid profiles

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